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Standardized butterbur extract Petadolex®—herbal approach to migraine prophylaxis


The development of a standardized extract of the rhizome of butterbur (Petasites hybridus) has led to a new clinical approach to the management of migraine headache. Two clinical trials with a standardized CO2 extract (Petadolex[R], Weber & Weber International GmbH & Co., Germany) have successfully demonstrated the extractis ability to safely and effectively reduce the frequency and intensity of migraine headaches.....

... The leaves, rhizome, and roots of butterbur contain a mixture of eremophilan-type sesquiterpenes consisting primarily of petasin and isopetasin. (4) According to phytotherapy textbooks, petasin and isopetasin have both spasmolytic and analgesic actions. (5) These active constituents also inhibit leukotriene synthesis, which may also contribute to butterburis antispasmodic and anti-inflammatory actions. (6)





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Townsend Letter for Doctors and Patients, Oct, 2002, by Donald J. Brown
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