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Showing posts from November, 2008

Rhymes with eggplant... Telcagepant!

In this article in Healthy Daily it discuses a new migraine abortive. Sounds exciting really. New research into the anatomy of a migraine has led to different angles to attack the problem.

Telcagepant is from a different class, called calcitonin gene-related peptide (CGRP) antagonists. It's believed that brain concentrations of CGRP are elevated during a migraine. CGRP antagonists don't seem to have blood vessel narrowing properties and, therefore, may not carry the same cardiovascular-related risks as triptans.

the pain and associated symptoms of migraine were thought to be caused by problems in brain blood vessels. But over the past 15 years, research has begun to change our understanding of the causes of migraine. New studies suggest that migraine may instead be a disorder of the nervous system. Certain small chemical messengers in the brain, including one known as calcitonin gene related peptide (CGRP), have been identified as potential mediators of migraine pain. New res…