Well, look at that... some research into why chronic migraines are chronic!
Chronic migraine is a prevalent healthcare burden whose cause is only partly known, a void that hampers development of new treatments. Considerable research shows that chronic pain, including that from migraine, may alter pain pathways so that they are more sensitive. This effect involves cytokines, small molecules first recognized for their role in signaling between immune cells. We hypothesized that pro-inflammatory cytokines produced after migraine could make it easier to trigger subsequent migraines as modeled by spreading depression, a most likely cause of migraine pain and aura.Well, look at that... some research on why chronic migraines are chronic!
We confirmed this hypothesis by triggering spreading depression in hippocampal slice cultures, thin sections of brain that can be kept in a dish for months. We found that spreading depression triggered cytokine changes in the brain that both increased and decreased susceptibility to spreading depression on subsequent days. Importantly, we also identified cytokine changes from neurons that prevented this increased susceptibility to spreading depression. Our work is the first to show that the interplay of cytokine changes between microglia and neurons may be ideal targets for the development of novel therapeutics to prevent migraine and its transformation to chronic migraine Migraine research foundation