Skip to main content

Intranasal Oxytocin study for #chronic #migraine


Small study involving 40 patients with chronic migraines were treated with an agent referred to as TI-001 an intranasal version of the hormone oxytocin. Patients with chronic migraine who "received a dose of the agent and were asked to rate their pain, nausea, photophobia, and phonophobia on a 4-point scale (indicating severe, moderate, mild, or none) prior to and at 0.5, 1, 2, 4, and 24 hours.At from 2 to 4 hours, 64% of the patients who received the agent reported a reduction in pain by 2 categories (either from "severe to mild or none," or from "moderate to none") compared with only 27% of patients who received a placebo." Intranasal Oxytocin Looks Promising for Migraine

The body itself produces oxytocin to " induce labor and promote lactation, but its strongest release comes during sexual orgasm in both women and men. The current liquid intranasal formulation of the hormone is inhaled up one nostril to reach and cover the nasal mucosa, said Dr. Yeomans." Intranasal Oxytocin Looks Promising for Migraine "This intranasal method of delivery bypasses the blood-brain barrier and directly accesses the part of the nervous system that is involved in chronic migraine, he said. The idea, said Dr. Yeomans, is to concentrate the hormone in this trigeminal system to access oxytocin receptors and decrease pain-evoked neural activity and therefore head pain."

"Experiments in rats have demonstrated this scientific phenomenon: after application of oxytocin, the hormone is preferentially taken up throughout the trigeminal system. "It goes directly to the trigeminal nerve, which provides all the pain information from the head," explained Dr. Yeomans. "If you put oxytocin in the nose of rat, you see high concentrations all through the trigeminal system, so it's really concentrating there."
The researchers noted that those patients who had taken a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin or ibuprofen prior to treatment did much worse than those who did not take such a drug. None of the patients who took an NSAID responded at the half-hour or 1-hour time points, and many fewer responded the rest of time compared with those not taking an NSAID.

Dr. Yeomans explained that inflammation causes a 5-fold increase in oxytocin receptors in the trigeminal system, "so there's a whole lot more for oxytocin to target," but an NSAID will block this inflammation.
The study also found that compared with placebo, the nasal oxytocin decreased the percentage of patients with nausea, photophobia, and phonophobia."
 Intranasal Oxytocin Looks Promising for Migraine 
The company is now involved with a larger study involving 100 patients to test the efficacy, tolerability and safety of the medication. With a phase 3 study likely to follow a year from now. Hypothetically this sort of product could be available within three years assuming the studies go well. Certainly an interesting study and treatment option. It will be interesting to see what develops from it.


Post a Comment

Popular posts from this blog

Signs the pain is getting the best of you

100 Symptoms of Fibromyalgia

There was a site that had this and I had linked to it on Tumblr but it is gone. So I had to hunt down someone who found my post and posted the whole thing in a forum. Anyway it is around but I'm posting it here so I will not have to hunt it down to reference it. Now we all know the major symptoms are the wide-spread pain, but our pain isn't just muscle pain... it can be nerve types of pain as well, and the fatigue and the insomnia. And even among symptoms there are some far more frequent than others, but it should be said we have categories... like the cognitive dysfunction, which is a broad one that has more than one symptom and we often just say fibrofog. The insomnia... more than one sleeping disorder. So the list is interesting.




GENERAL
__ Fatigue, made worse by physical exertion or stress
__ Activity level decreased to less than 50% of pre-illness activity level
__ Recurrent flu-like illness
__ Sore throat
__ Hoarseness
__ Tender or swollen lymph nodes (glands), especiall…

When I say I am good

When people ask me how I am feeling 99% of the time I am lying. I often say 'not bad', because I feel it is slightly more honest than 'good' or 'fine'. Got sick of fine. Anyway, I lie for many reasons. 



I'm having a good pain day: They happen and I'll say that I'm good, fine, not bad. I even feel like I can accomplish great things... in moderation. In which case, relatively speaking, for Me I am not actually lying. This is a Good pain day, it is Not Bad for me and I am Fine with it. I just don't want to explain: I just don't want to explain how crappy I feel and in which way I mean. Because I am tired of it. I just want to deal with it, without having to discuss it, mention it or have any sympathy expressed about it. Because it can be complicated. It may be a migraine with specific symptoms. Maybe it is a FM flare though. Or both. And then I have to explain what it is because most people think my migraines are the main issue but I could be FM…