Skip to main content

Migraine is associated with variations in structure of brain arteries

Migraine is associated with variations in structure of brain arteries

A new study done by researchers at the Perelman School of Medicine at the University of Pennsylvania have found that the net of arteries supplying blood to the brain is more likely to be incomplete in people who have migraines. Say what? That is what I said. Essentially, "Variations in arterial anatomy lead to asymmetries in cerebral blood flow that might contribute to the process triggering migraines."



"The arterial supply of blood to the brain is protected by a series of connections between the major arteries, termed the "circle of Willis" after the English physician who first described it in the 17th century. People with migraine, particularly migraine with aura, are more likely to be missing components of the circle of Willis."

 There was once the theory we are all familiar with that migraines were caused by dilation of blood vessels in the head... but more recent studies have shown it is attributed to abnormal neuronal signals.  Now this study, which appears in PLOS ONE, suggests blood vessels have a different role in the game... these structural alterations of the blood supply to the brain itself may increase "susceptibility to changes in cerebral blood flow, contributing to the abnormal neuronal activity that starts migraine."



"People with migraine actually have differences in the structure of their blood vessels - this is something you are born with," said the study's lead author, Brett Cucchiara, MD, Associate Professor of Neurology. "These differences seem to be associated with changes in blood flow in the brain, and it's possible that these changes may trigger migraine, which may explain why some people, for instance, notice that dehydration triggers their headaches."
 The study involved 170 people divided into three groups: a control group with no headaches, those with migraine with aura and those with migraine without aura. The researchers found that an incomplete Willis was more common in the group with migraine with aura (73%) and the migraine without aura (67%) compared to the control group (51%). They used magnetic resonance angiography to determine blood vessel stricture and a noninvasive magnetic resonance imaging method called Arterial spin labeling (ASL) developed at the University of Pennsylvania to measure changed in the cerebral blood flow.


"Abnormalities in both the circle of Willis and blood flow were most prominent in the back of the brain, where the visual cortex is located. This may help explain why the most common migraine auras consist of visual symptoms such as seeing distortions, spots, or wavy lines," said the study's senior author, John Detre, MD, Professor of Neurology and Radiology.


Post a Comment

Popular posts from this blog

Signs the pain is getting the best of you

100 Symptoms of Fibromyalgia

There was a site that had this and I had linked to it on Tumblr but it is gone. So I had to hunt down someone who found my post and posted the whole thing in a forum. Anyway it is around but I'm posting it here so I will not have to hunt it down to reference it. Now we all know the major symptoms are the wide-spread pain, but our pain isn't just muscle pain... it can be nerve types of pain as well, and the fatigue and the insomnia. And even among symptoms there are some far more frequent than others, but it should be said we have categories... like the cognitive dysfunction, which is a broad one that has more than one symptom and we often just say fibrofog. The insomnia... more than one sleeping disorder. So the list is interesting.




GENERAL
__ Fatigue, made worse by physical exertion or stress
__ Activity level decreased to less than 50% of pre-illness activity level
__ Recurrent flu-like illness
__ Sore throat
__ Hoarseness
__ Tender or swollen lymph nodes (glands), especiall…

When I say I am good

When people ask me how I am feeling 99% of the time I am lying. I often say 'not bad', because I feel it is slightly more honest than 'good' or 'fine'. Got sick of fine. Anyway, I lie for many reasons. 



I'm having a good pain day: They happen and I'll say that I'm good, fine, not bad. I even feel like I can accomplish great things... in moderation. In which case, relatively speaking, for Me I am not actually lying. This is a Good pain day, it is Not Bad for me and I am Fine with it. I just don't want to explain: I just don't want to explain how crappy I feel and in which way I mean. Because I am tired of it. I just want to deal with it, without having to discuss it, mention it or have any sympathy expressed about it. Because it can be complicated. It may be a migraine with specific symptoms. Maybe it is a FM flare though. Or both. And then I have to explain what it is because most people think my migraines are the main issue but I could be FM…