There looks to be a promising new Fibromyalgia drug on the horizon. Check out Drug Under Development Spells Hope for Pain Relief in Fibromyalgia. As we all know current medications yield poor results with Lyrica in the lead but still not by much. I find this intriguing given it comes from Omega-3 fatty acids.
"Probably the most intriguing [new development] is a compound called neuroprotectin D1 (NPD1) – the subject of increasingly intense investigation. NPD1 has been mostly investigated as a protective agent in central nervous system, eye and kidney disorders but a recent study suggested it may be effective against the hardest to treat pain of all – nerve pain.
Enter a potentially cheap drug derived from a fatty acid often used in chronic fatigue syndrome and fibromyalgia.
A ‘Good’ Fatty Acid Derivative
“These compounds are derived from omega-3 fatty acids found in fish oil, but are 1,000 times more potent than their precursors in reducing inflammation,” Ru Rong JiDerived from DHA, an omega-3 fatty acid found in fish oils, NPD1 has neuroprotective properties.
In contrast to omega-6 fatty acids, which have pro-inflammatory effects, omega-3 fatty acids have anti-inflammatory effects. Studies have not generally borne out their efficacy in ME/CFS but they are commonly recommended and used. With NPD1 clocking in at about 1,000 times the potency of its precursor, DHA, NPDI – if it ever gets to market – will be like fish oil on speed.
NPD1 is potentially much more than a pain reliever; indeed, pain is only the latest symptom NPD1 is being thrown at. An aptly named drug, neuroprotectin D1 is produced in response to a variety of conditions, some of which occur in chronic fatigue syndrome and fibromyalgia, including oxidative stress (high in ME/CFS/FM), protein misfolding (perhaps occurring in ME/CFS), seizures and brain ischemia-reperfusion (conjectured to occur in ME/CFS/FM)."