Skip to main content

Brain Signal Disruption in Fibromyalgia Patients

Brain Signal Disruption in Fibromyalgia Patients

Fibromyalgia pain dysfunction involves an increased sensitivity to pain known as hyperalgesia. New research suggests that a disruption of brain signals for reward and punishment contributes to this increased pain sensitivity. The results published in Arthritis & Rheumatism, a journal of the American College of Rheumatology, suggests that it is this altered brain processing that could contribute to the widespread pain felt by people with fibromyalgia as well as the lack of response to opioid therapy in patients.

In people“'with fibromyalgia there is an alteration in the central nervous system pain processing and a poor response to topical pain treatments, trigger point injections and opioids,' said lead author Dr. Marco Loggia from Massachusetts General Hospital and Harvard Medical School in Boston.”



Pain dysfunction in the brain of people with FM, and the brains of people with chronic pain, affects more than a few areas of the brain. We often think pain is this signal sent out and it is cut and dry, but it isn't... there is a lot of interpretation going on in the brain, lots of areas lighting up in there for the process. So lots of areas go... wonky and more than one neurotransmitter is involved in that. Which is what we see in FM. High levels of substance P, lower levels of dopamine which can help to dampen a pain signal that is deemed by the brain to be insignificant... and this is the regular state of affairs as it were. So to think that someone's brain with FM would respond the same to pain anticipation and pain relief anticipation would be quite odd. In fact given the normal state of affairs is heightened pain to all pain stimulus, which endures beyond the actual stimulus, one would think it would not react the same way to pain relief anticipation... because the person does not actual anticipate pain relief the same way as a healthy individual does. So I am not sure we can say this is the cause of the heightened pain experience as it seems it would be more of an effect of chronic pain itself. I wish they had added in other people with other chronic pain conditions to correlate it to.
Post a Comment

Popular posts from this blog

Signs the pain is getting the best of you

100 Symptoms of Fibromyalgia

There was a site that had this and I had linked to it on Tumblr but it is gone. So I had to hunt down someone who found my post and posted the whole thing in a forum. Anyway it is around but I'm posting it here so I will not have to hunt it down to reference it. Now we all know the major symptoms are the wide-spread pain, but our pain isn't just muscle pain... it can be nerve types of pain as well, and the fatigue and the insomnia. And even among symptoms there are some far more frequent than others, but it should be said we have categories... like the cognitive dysfunction, which is a broad one that has more than one symptom and we often just say fibrofog. The insomnia... more than one sleeping disorder. So the list is interesting.




GENERAL
__ Fatigue, made worse by physical exertion or stress
__ Activity level decreased to less than 50% of pre-illness activity level
__ Recurrent flu-like illness
__ Sore throat
__ Hoarseness
__ Tender or swollen lymph nodes (glands), especiall…

When I say I am good

When people ask me how I am feeling 99% of the time I am lying. I often say 'not bad', because I feel it is slightly more honest than 'good' or 'fine'. Got sick of fine. Anyway, I lie for many reasons. 



I'm having a good pain day: They happen and I'll say that I'm good, fine, not bad. I even feel like I can accomplish great things... in moderation. In which case, relatively speaking, for Me I am not actually lying. This is a Good pain day, it is Not Bad for me and I am Fine with it. I just don't want to explain: I just don't want to explain how crappy I feel and in which way I mean. Because I am tired of it. I just want to deal with it, without having to discuss it, mention it or have any sympathy expressed about it. Because it can be complicated. It may be a migraine with specific symptoms. Maybe it is a FM flare though. Or both. And then I have to explain what it is because most people think my migraines are the main issue but I could be FM…