Skip to main content

#Migraines, #depression and allodynia

Migraines and depression have been linked in studies before, suggesting a higher comorbidity of the two especially with migraines with aura.

This study: Allodynia is associated with a higher prevalence of depression in migraine patients  aimed to identify migraine-specific factors involved in the association of depression and migraines.

  • 3,624 migraineurs within the LUMINA project were sent a depression questionnaire
  • (mean age: 41.7 11.9) based on migraine diagnosis. 
  • 3,177 (87.7%) returned this depression questionnaire. 
  • 2,533 were eventually included in the analysis because the questionnaires of the others were incomplete. (Migraine and Depression - Study Shows Allodynia Is a Factor)


Results (Source: Migraine and Depression - Study Shows Allodynia Is a Factor)

  • Of the 2,533 eligible migraineurs who participated in the study, 1,137 (45%) experienced lifetime depression.
  • Of the 2,533 eligible migraineurs who participated in the study, 1,767 (70%) experienced allodynia (a condition in which an ordinarily painless stimulus is experienced as being painful) during migraine attacks.
Significant associations with depression were found for several migraine-specific variables, including:
  • attack frequency,
  • number of migraine days,
  • use of preventive medication, and
  • allodynia


Significant associations with depression were found for several variables that were not migraine-specific 
  •  poor quality sleep, sleep disturbances;
  • gender (female)
  • body mass index (BMI) (higher);
  • level of education (lower);
  • smoking; and
  • low alcohol consumption

The study concludes that "allodynia, in addition to high migraine attack frequency, as a new migraine-specific factor associated with depression." Also "Pathophysiologically, the triad migraine, depression and allodynia may suggest a self-reinforcing dysfunction of central nervous system (CNS) structures involved in the modulation of neuronal excitability and pain."

 Studies looking at allodynia and migraine are fascinating in themselves to me because what that suggests about migraines is interesting to me. Also I have it so it is always interesting to know more about it. What factors contribute to these comorbid conditions is quite fascinating and what possible connections they may have.
Post a Comment

Popular posts from this blog

Signs the pain is getting the best of you

100 Symptoms of Fibromyalgia

There was a site that had this and I had linked to it on Tumblr but it is gone. So I had to hunt down someone who found my post and posted the whole thing in a forum. Anyway it is around but I'm posting it here so I will not have to hunt it down to reference it. Now we all know the major symptoms are the wide-spread pain, but our pain isn't just muscle pain... it can be nerve types of pain as well, and the fatigue and the insomnia. And even among symptoms there are some far more frequent than others, but it should be said we have categories... like the cognitive dysfunction, which is a broad one that has more than one symptom and we often just say fibrofog. The insomnia... more than one sleeping disorder. So the list is interesting.




GENERAL
__ Fatigue, made worse by physical exertion or stress
__ Activity level decreased to less than 50% of pre-illness activity level
__ Recurrent flu-like illness
__ Sore throat
__ Hoarseness
__ Tender or swollen lymph nodes (glands), especiall…

When I say I am good

When people ask me how I am feeling 99% of the time I am lying. I often say 'not bad', because I feel it is slightly more honest than 'good' or 'fine'. Got sick of fine. Anyway, I lie for many reasons. 



I'm having a good pain day: They happen and I'll say that I'm good, fine, not bad. I even feel like I can accomplish great things... in moderation. In which case, relatively speaking, for Me I am not actually lying. This is a Good pain day, it is Not Bad for me and I am Fine with it. I just don't want to explain: I just don't want to explain how crappy I feel and in which way I mean. Because I am tired of it. I just want to deal with it, without having to discuss it, mention it or have any sympathy expressed about it. Because it can be complicated. It may be a migraine with specific symptoms. Maybe it is a FM flare though. Or both. And then I have to explain what it is because most people think my migraines are the main issue but I could be FM…